Gene

usp48

ID

ZDB-GENE-050522-197

Name

ubiquitin specific peptidase 48

Symbol

usp48 Nomenclature History

Previous Names

im:7139343
zgc:112364 (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. Involved in cranial skeletal system development. Orthologous to human USP48 (ubiquitin specific peptidase 48).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7139343 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With usp48 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Deafness, autosomal dominant 85	620227

Associated With usp48 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018200	Ubiquitin specific protease, conserved site
Domain	IPR000626	Ubiquitin-like domain
Domain	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain	IPR006615	Peptidase C19, ubiquitin-specific peptidase, DUSP domain
Domain	IPR028889	Ubiquitin specific protease domain
Domain	IPR033841	Ubiquitin-specific peptidase 48
Domain	IPR044743	Ubiquitin-specific-processing protease 48, Ubl domain
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR035927	DUSP-like superfamily
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily

Domain Details Per Protein

Protein	Length	DUSP-like superfamily	Papain-like cysteine peptidase superfamily	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	Peptidase C19, ubiquitin-specific peptidase, DUSP domain	Ubiquitin-like domain	Ubiquitin-like domain superfamily	Ubiquitin-specific peptidase 48	Ubiquitin-specific-processing protease 48, Ubl domain	Ubiquitin specific protease, conserved site	Ubiquitin specific protease domain
UniProtKB:A0A0R4IB93 InterPro	1047

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	usp48-202 (1) Ensembl	Havana	4226 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	usp48-203 (1) Ensembl	Havana	1867 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations