ZFIN ID: ZDB-GENE-050522-154
Gene Name: leucine zipper-EF-hand containing transmembrane protein 1
Gene Symbol: letm1    Nomenclature History

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Previous Names: fc31h08, fc58h01, wu:fc31h08 (1), wu:fc58h01 (1), zgc:109969 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have calcium:proton antiporter activity. Predicted to be involved in cellular calcium ion homeostasis and protein complex oligomerization. Predicted to localize to mitochondrial inner membrane. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1).
Genome Resources: Alliance (1),  Gene:570745 (1),  Ensembl(GRCz11):ENSDARG00000056978 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:109969]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018390Tg Transgenic Insertion Unknown Unknown DNA
sa18160 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH letm1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH letm1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium export from the mitochondrion (more)
    Cellular Component mitochondrial inner membrane (more)
    Molecular Function calcium:proton antiporter activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA letm1-201 (1)    Ensembl 2738
    ncRNA letm1-002 (1)    Ensembl 1055
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM letm1 No data available
    MARKER RELATIONSHIPS
    letm1 Contained in: [BAC] CH211-195N12 (1)
    letm1 Encodes: [EST] fc31h08, fc58h01
    [cDNA] MGC:109969 (1), MGC:191626 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001045208 (1)
    Genomic GenBank:CR556722 (1) 205873 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IDC7 (1) 768 aa
    Sequence Information (all 29)
    ORTHOLOGY for letm1 ( Chr: 13 )
    CITATIONS (28)