ZFIN ID: ZDB-GENE-050522-144
Gene Name: phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog a
Gene Symbol: pde6ga    Nomenclature History

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Previous Names: zgc:112320 (1), zgc:153837, zgc:158528

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have 3',5'-cyclic-nucleotide phosphodiesterase activity and cGMP binding activity. Predicted to be involved in activation of MAPK activity; positive regulation of G protein-coupled receptor signaling pathway; and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to localize to the photoreceptor outer segment membrane. Is expressed in epiphysis; retinal photoreceptor layer; and retinal rod cell. Orthologous to human PDE6H (phosphodiesterase 6H).
Genome Resources: Alliance (1),  Gene:553708 (1),  Ensembl(GRCz11):ENSDARG00000056791 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 2 publications
Directly Submitted Expression Data: 7 figures (6 images) from Thisse et al., 2004 [MGC:112320]
Wild-type Stages, Structures: Pharyngula:Prim-15 (30.0h-36.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31321 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40039 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pde6ga
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pde6ga HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pde6ga VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process visual perception (more)
    Cellular Component photoreceptor outer segment membrane (more)
    Molecular Function 3',5'-cyclic-nucleotide phosphodiesterase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR006952 Retinal cGMP phosphodiesterase, gamma subunit
    Homologous_superfamily IPR037030 Retinal cGMP phosphodiesterase, gamma subunit superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pde6ga No data available
    MARKER RELATIONSHIPS
    pde6ga Encodes: [cDNA] MGC:112320 (1), MGC:153837 (1), MGC:158528 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001159826 (1)
    Polypeptide UniProtKB:Q502C6 (1) 86 aa
    Sequence Information (all 16)
    ORTHOLOGY for pde6ga ( Chr: 3 )
    CITATIONS (16)