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ZIRC
ZFIN ID: ZDB-GENE-050522-116
Gene Name: glutathione reductase
Gene Symbol: gsr    Nomenclature History

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Previous Name: zgc:110010 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have flavin adenine dinucleotide binding activity and glutathione-disulfide reductase activity. Predicted to be involved in cell redox homeostasis; cellular response to oxidative stress; and glutathione metabolic process. Predicted to localize to the cytosol and mitochondrion. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Is expressed in intestinal bulb; liver; and macrophage. Orthologous to human GSR (glutathione-disulfide reductase).
Genome Resources: Alliance (1),  Gene:553575 (1),  Ensembl(GRCz11):ENSDARG00000019236 (1)
GENE EXPRESSION
All Expression Data: 13 figures from 6 publications
Directly Submitted Expression Data: 7 figures (12 images) from Thisse et al., 2004 [MGC:110010]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa15125 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39011 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gsr
    2
    CRISPR2-gsr
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gsr HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hemolytic anemia due to glutathione reductase deficiency 618660
    DISEASE ASSOCIATED WITH gsr VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell redox homeostasis (more)
    Cellular Component cytoplasm (more)
    Molecular Function electron transfer activity (more)
    GO Terms (all 14)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript gsr-205 (1)    Ensembl 870
    mRNA gsr-201 (1)    Ensembl 1976
    gsr-206 (1)    Ensembl 1318
    gsr-207 (1)    Ensembl 895
    gsr-208 (1)    Ensembl 660
    ncRNA gsr-003 (1) 814
    gsr-004 (1)    Ensembl 567
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gsr
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgFOS(gsr:EGFP) gsr EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    gsr Contained in: [BAC] CH211-127L12 (1) (order this), CH211-195B11 (1) (order this)
    gsr Encodes: [cDNA] MGC:110010 (1) (order this), MGC:192656 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020554 (1) 2000 bp
    Genomic GenBank:BX005218 (1) 183670 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8RQT4 (1) 500 aa
    Sequence Clusters UniGene:83699 (1)
    Sequence Information (all 29)
    ORTHOLOGY for gsr ( Chr: 14 )
    CITATIONS (47)