ZFIN ID: ZDB-GENE-050522-100
Gene Name: ORAI calcium release-activated calcium modulator 1b
Gene Symbol: orai1b    Nomenclature History

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Previous Names: orai1, im:7146264, zgc:109721

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have store-operated calcium channel activity. Involved in sarcomere organization. Predicted to localize to integral component of plasma membrane. Is expressed in brain; heart; liver; and myotome. Human ortholog(s) of this gene implicated in primary immunodeficiency disease and tubular aggregate myopathy 1. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1).
Genome Resources: Alliance (1),  Gene:402892 (1),  Ensembl(GRCz11):ENSDARG00000004154 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7146264]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-orai1b N/A 1
MO2-orai1b N/A 1
DISEASE ASSOCIATED WITH orai1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
tubular aggregate myopathy 2 Alliance Myopathy, tubular aggregate, 2 615883
Immunodeficiency 9 612782
DISEASE ASSOCIATED WITH orai1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process sarcomere organization (more)
Cellular Component integral component of plasma membrane (more)
Molecular Function store-operated calcium channel activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA orai1b-201 (1)    Ensembl 1299
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM orai1b No data available
MARKER RELATIONSHIPS
orai1b Contained in: [BAC] CH73-20G22 (1)
orai1b Encodes: [EST] IMAGE:7146264 (1)
[cDNA] MGC:109721 (1), MGC:192510 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_205600 (1) 1231 nt
Genomic GenBank:CU928082 (1) 85107 nt
Select Tool
Polypeptide UniProtKB:A0A0R4I9A7 (1) 222 aa
Sequence Information (all 17)
ORTHOLOGY for orai1b ( Chr: 10 )
CITATIONS (22)