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General Information
ZIRC
ZFIN ID: ZDB-GENE-050518-2
Gene Name: low density lipoprotein receptor-related protein 5
Gene Symbol: lrp5
Sequence Ontology ID : SO:0001217

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Previous Name: LRP6

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(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in animal organ development; canonical Wnt signaling pathway; and sensory perception of sound. Predicted  ...
DISEASE ASSOCIATED WITH lrp5 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
autosomal dominant endosteal hyperostosis Hyperostosis, endosteal 144750
Osteosclerosis 144750
autosomal dominant osteopetrosis 1 Osteopetrosis, autosomal dominant 1 607634
exudative vitreoretinopathy 4 Exudative vitreoretinopathy 4 601813
osteoporosis {Osteoporosis} 166710
osteoporosis-pseudoglioma syndrome Osteoporosis-pseudoglioma syndrome 259770
Worth's syndrome van Buchem disease, type 2 607636
Polycystic liver disease 4 with or without kidney cysts 617875
[Bone mineral density variability 1] 601884
DISEASE ASSOCIATED WITH lrp5 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
nonsyndromic deafness WT + MO5-lrp5 + MO6-lrp5 standard conditions Xia et al., 2017
GENE ONTOLOGY
Ontology GO Term
Biological Process liver development (more)
Cellular Component integral component of membrane (more)
Molecular Function Wnt-activated receptor activity (more)
GO Terms (all 14)
TRANSCRIPTS No data available
GENE PRODUCT DESCRIPTION
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM lrp5 No data available
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001177458 (1) 4390 bp
Genomic GenBank:FO704597 (1) 86457 bp
Select Tool
Polypeptide UniProtKB:F1QTJ4 (1) 1615 aa
Sequence Clusters UniGene:105028 (1)
Sequence Information (all 20)
OTHER lrp5 GENE PAGES
  • Alliance (1)
  • Gene:568518 (1)
  • Ensembl(GRCz11):ENSDARG00000006921 (2)
  • ORTHOLOGY for lrp5 ( Chr: 25 )
    CITATIONS (30)