Gene

abcg8

ID
ZDB-GENE-050517-41
Name
ATP-binding cassette, sub-family G (WHITE), member 8
Symbol
abcg8 Nomenclature History
Previous Names
  • sterolin 2
  • zgc:172358
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and ATPase activity. Predicted to be involved in cholesterol homeostasis. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Pinto et al., 2016
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With abcg8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
gallbladder disease Alliance {Gallbladder disease 4} 611465
sitosterolemia Alliance Sitosterolemia 1 210250
Associated With abcg8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017871 ABC transporter, conserved site
Domain IPR003439 ABC transporter-like
Domain IPR003593 AAA+ ATPase domain
Domain IPR013525 ABC-2 type transporter
Domain IPR043926 ABC transporter family G domain
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length AAA+ ATPase domain ABC-2 type transporter ABC transporter, conserved site ABC transporter family G domain ABC transporter-like P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1QCP3 332
UniProtKB:A8WGD3 332
UniProtKB:A0A0R4IJR4 675
UniProtKB:A0A0R4IGG8 676
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations