ZFIN ID: ZDB-GENE-050517-41
Gene Name: ATP-binding cassette, sub-family G (WHITE), member 8
Gene Symbol: abcg8    Nomenclature History

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Previous Names: sterolin 2, zgc:172358

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to contribute to cholesterol transfer activity. Predicted to be involved in cholesterol homeostasis and transmembrane transport. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8).
Genome Resources: Alliance (1),  Gene:100136850 (1),  Ensembl(GRCz11):ENSDARG00000063059 (1)
GENE EXPRESSION
All Expression Data: Fig. 2 from Pinto et al., 2016
PHENOTYPE No data available
DISEASE ASSOCIATED WITH abcg8 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
gallbladder disease Alliance {Gallbladder disease 4} 611465
sitosterolemia Alliance Sitosterolemia 1 210250
DISEASE ASSOCIATED WITH abcg8 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cholesterol homeostasis (more)
Cellular Component integral component of membrane (more)
Molecular Function ATPase activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR003439 ABC transporter-like
Domain IPR003593 AAA+ ATPase domain
Domain IPR013525 ABC-2 type transporter
Conserved_site IPR017871 ABC transporter, conserved site
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA abcg8-201 (1)    Ensembl 1386
abcg8-203 (1)    Ensembl 2476
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM abcg8 No data available
MARKER RELATIONSHIPS
abcg8 Contained in: [BAC] CH211-227C6 (1)
abcg8 Encodes: [cDNA] MGC:172358 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001114569 (1) 1414 bp
Genomic GenBank:AL928999 (1) 169570 bp
Select Tool
Polypeptide UniProtKB:A0A0R4IGG8 (1) 676 aa
Sequence Information (all 15)
ORTHOLOGY for abcg8 ( Chr: 13 )
CITATIONS (23)