Gene
abcg8
- ID
- ZDB-GENE-050517-41
- Name
- ATP-binding cassette, sub-family G (WHITE), member 8
- Symbol
- abcg8 Nomenclature History
- Previous Names
-
- sterolin 2
- zgc:172358
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have ATPase-coupled transmembrane transporter activity. Predicted to be involved in cholesterol homeostasis and transmembrane transport. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Pinto et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| gallbladder disease | Alliance | {Gallbladder disease 4} | 611465 |
| sitosterolemia | Alliance | Sitosterolemia 1 | 210250 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR013525 | ABC-2 type transporter, transmembrane domain |
| Domain | IPR043926 | ABC transporter family G domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC-2 type transporter, transmembrane domain | ABC transporter family G domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IJR4
|
675 | ||||||
|
UniProtKB:A0A0R4IGG8
|
676 | ||||||
|
UniProtKB:A0A8M1NFQ3
|
684 |
Interactions and Pathways
No data available
Plasmids
No data available