ZFIN ID: ZDB-GENE-050517-3
Gene Name: ATP-binding cassette, sub-family A (ABC1), member 4a
Gene Symbol: abca4a    Nomenclature History

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Previous Name: zgc:91823

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and phospholipid transporter activity. Predicted to be involved in lipid transport. Predicted to localize to intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in fundus dystrophy and retinal degeneration (multiple). Orthologous to human ABCA4 (ATP binding cassette subfamily A member 4).
Genome Resources: Alliance (1),  Gene:798993 (1),  Ensembl(GRCz11):ENSDARG00000057169 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022972Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11328 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39458 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-abca4a
    2
    CRISPR2-abca4a
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH abca4a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    age related macular degeneration 2 Alliance {Macular degeneration, age-related, 2} 153800
    cone-rod dystrophy 3 Alliance Cone-rod dystrophy 3 604116
    retinitis pigmentosa 19 Alliance Retinitis pigmentosa 19 601718
    Stargardt disease Alliance Fundus flavimaculatus 248200
    Retinal dystrophy, early-onset severe 248200
    Stargardt disease 1 248200
    DISEASE ASSOCIATED WITH abca4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process transmembrane transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA abca4a-202 (1)    Ensembl 7045
    abca4a-203 (1)    Ensembl 1421
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM abca4a No data available
    MARKER RELATIONSHIPS
    abca4a Contained in: [BAC] CH211-266K13 (1)
    abca4a Encodes: [cDNA] MGC:91823 (1), MGC:191808 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002206 (1) 1415 nt
    Genomic GenBank:CR759826 (1) 151652 nt
    Select Tool
    Polypeptide UniProtKB:E9QD15 (1) 2277 aa
    Sequence Information (all 13)
    ORTHOLOGY for abca4a ( Chr: 24 )
    CITATIONS (29)