ZFIN ID: ZDB-GENE-050517-27
Gene Name: ATP-binding cassette, sub-family D (ALD), member 1
Gene Symbol: abcd1    Nomenclature History

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Previous Name: zgc:172102 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have long-chain fatty acid transporter activity. Involved in several processes, including oligodendrocyte development; positive regulation of myelination; and swimming behavior. Predicted to localize to peroxisome. Is expressed in central nervous system; floor plate; gut; interrenal gland; and pronephros. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to several human genes including ABCD1 (ATP binding cassette subfamily D member 1).
Genome Resources: Alliance (1),  Gene:566367 (1),  Ensembl(GRCz11):ENSDARG00000074876 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa509 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21198 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34298 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41121 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zc90 Insertion Unknown Unknown TALEN
    zc91 Unknown Exon 1 Unknown TALEN
    zc92 Unknown Exon 1 Unknown TALEN
    zc94 Unknown Exon 1 Unknown TALEN
    zc93 Unknown Exon 1 Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-abcd1 N/A 1
    TALEN1-abcd1 1
    DISEASE ASSOCIATED WITH abcd1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    adrenoleukodystrophy Alliance Adrenoleukodystrophy 300100
    Adrenomyeloneuropathy, adult 300100
    DISEASE ASSOCIATED WITH abcd1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    adrenoleukodystrophy abcd1sa509/sa509 standard conditions Strachan et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adrenal gland development (more)
    Cellular Component peroxisome (more)
    Molecular Function long-chain fatty acid transporter activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA abcd1-201 (1)    Ensembl 2341
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM abcd1 No data available
    MARKER RELATIONSHIPS
    abcd1 Contained in: [BAC] CH211-169P10 (1)
    abcd1 Encodes: [cDNA] MGC:172102 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001111186 (1) 2024 nt
    Genomic GenBank:BX005406 (1) 132872 nt
    Select Tool
    Polypeptide UniProtKB:F1RBC8 (1) 766 aa
    Sequence Information (all 12)
    ORTHOLOGY for abcd1 ( Chr: 8 )
    CITATIONS (34)