ZFIN ID: ZDB-GENE-050517-22
Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Gene Symbol: abcc8    Nomenclature History

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Previous Name: zSur1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to localize to membrane. Is expressed in diencephalon; forebrain; hindbrain; and midbrain. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 1; hyperinsulinism; hypertension; and type 2 diabetes mellitus. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8).
Genome Resources: Alliance (1),  Gene:553281 (1),  Ensembl(GRCz11):ENSDARG00000051879 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13411 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15863 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38076 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44308 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-abcc8 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH abcc8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial hyperinsulinemic hypoglycemia 1 Alliance Hyperinsulinemic hypoglycemia, familial, 1 256450
    transient neonatal diabetes mellitus Alliance Diabetes mellitus, transient neonatal 2 610374
    type 2 diabetes mellitus Alliance Diabetes mellitus, noninsulin-dependent 125853
    Diabetes mellitus, permanent neonatal 3, with or without neurologic features 618857
    Hypoglycemia of infancy, leucine-sensitive 240800
    DISEASE ASSOCIATED WITH abcc8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process potassium ion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript abcc8-202 (1)    Ensembl 4850
    mRNA abcc8-203 (1)    Ensembl 1401
    abcc8-204 (1)    Ensembl 4746
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM abcc8 No data available
    MARKER RELATIONSHIPS
    abcc8 Contained in: [BAC] CH211-278A17 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001172647 (1) 4947 nt
    Genomic GenBank:CR759741 (1) 165845 nt
    Select Tool
    Polypeptide UniProtKB:F1QMZ9 (1) 1594 aa
    Sequence Information (all 25)
    ORTHOLOGY for abcc8 ( Chr: 25 )
    CITATIONS (24)