ZFIN ID: ZDB-GENE-050517-18
Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 6a
Gene Symbol: abcc6a    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have ATPase-coupled transmembrane transporter activity. Involved in chordate embryonic development and regulation of bone mineralization. Predicted to localize to membrane. Is expressed in Kupffer's vesicle; forerunner cell group; opercular flap; and tail bud. Human ortholog(s) of this gene implicated in arterial calcification of infancy; coronary artery disease; and pseudoxanthoma elasticum. Orthologous to human ABCC6 (ATP binding cassette subfamily C member 6).
Genome Resources: Alliance (1),  Gene:566555 (1),  Ensembl(GRCz11):ENSDARG00000016750 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu4958 Point Mutation Unknown Unknown
sa963 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2285 Point Mutation Unknown Premature Stop ENU
    sa31502 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33821 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40643 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-abcc6a
    1
    MO1-abcc6a N/A 3
    MO2-abcc6a N/A 2
    MO3-abcc6a N/A 1
    DISEASE ASSOCIATED WITH abcc6a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    arterial calcification of infancy Alliance Arterial calcification, generalized, of infancy, 2 614473
    pseudoxanthoma elasticum Alliance Pseudoxanthoma elasticum 264800
    Pseudoxanthoma elasticum, forme fruste 177850
    DISEASE ASSOCIATED WITH abcc6a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA abcc6a-201 (1)    Ensembl 6409
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM abcc6a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(abcc6a:GAL4FF) abcc6a GAL4FF Danio rerio 1 3
    MARKER RELATIONSHIPS
    abcc6a Contained in: [BAC] DKEY-176G1 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009302206 (1)
    Genomic GenBank:BX548046 (1) 168695 nt
    Select Tool
    Polypeptide UniProtKB:E7F118 (1) 1507 aa
    Sequence Information (all 7)
    ORTHOLOGY for abcc6a ( Chr: 6 )
    CITATIONS (28)