Gene

gcgrb

ID
ZDB-GENE-050516-2
Name
glucagon receptor b
Symbol
gcgrb Nomenclature History
Previous Names
  • GCGR (1)
  • GLP-1r (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Exhibits peptide hormone binding activity. Involved in regulation of glucose metabolic process. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in brain; intestine; and liver. Orthologous to several human genes including GCGR (glucagon receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Li et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gcgrb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mahvash disease 619290
Associated With gcgrb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017983 GPCR, family 2, secretin-like, conserved site
Domain IPR001879 GPCR, family 2, extracellular hormone receptor domain
Domain IPR017981 GPCR, family 2-like
Family IPR000832 GPCR, family 2, secretin-like
Family IPR001749 GPCR, family 2, gastric inhibitory polypeptide receptor
Family IPR003292 GPCR, family 2, glucagon-like peptide-1 receptor
Homologous_superfamily IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
Domain Details Per Protein
Protein Length GPCR, family 2, extracellular hormone receptor domain GPCR family 2, extracellular hormone receptor domain superfamily GPCR, family 2, gastric inhibitory polypeptide receptor GPCR, family 2, glucagon-like peptide-1 receptor GPCR, family 2-like GPCR, family 2, secretin-like GPCR, family 2, secretin-like, conserved site
UniProtKB:F1RCQ6 509
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations