ZFIN ID: ZDB-GENE-050508-5
Gene Name: fat storage inducing transmembrane protein 2
Gene Symbol: fitm2    Nomenclature History

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Previous Names: fit2, c20orf142, wu:fc04g08, wu:fr13b05, zgc:110840 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Involved in several processes, including glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to localize to the integral component of endoplasmic reticulum membrane. Is expressed in adaxial cell and slow muscle cell. Orthologous to human FITM2 (fat storage inducing transmembrane protein 2).
Genome Resources: Alliance (1),  Gene:552928 (1),  Ensembl(GRCz11):ENSDARG00000034568 (1)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (5 images) from Thisse et al., 2004 [IMAGE:7154803]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17319 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24343 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fitm2 N/A 1
    MO2-fitm2 N/A 1
    MO3-fitm2 N/A 1
    PHENOTYPE
    Data: 4 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH fitm2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Siddiqi syndrome 618635
    DISEASE ASSOCIATED WITH fitm2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endocrine pancreas development (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function molecular_function (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR019388 Fat storage-inducing transmembrane protein
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fitm2-201 (1)    Ensembl 1546
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fitm2 No data available
    MARKER RELATIONSHIPS
    fitm2 Contained in: [BAC] DKEY-21C19 (1) (order this)
    fitm2 Encodes: [EST] fc04g08, fr13b05, IMAGE:7154803 (1)
    [cDNA] MGC:110840 (1), MGC:174289 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020498 (1) 1570 bp
    Genomic GenBank:BX005414 (1) 236036 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4I9B7 (1) 252 aa
    Sequence Information (all 17)
    ORTHOLOGY for fitm2 ( Chr: 23 )
    CITATIONS (29)