ZFIN Gene: lrp8

ZFIN ID: ZDB-GENE-050506-134

ZFIN ID: ZDB-GENE-050506-134

Gene Name:

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Gene Symbol:

lrp8 Nomenclature History

Previous Names:

apoer2 (1), im:7145907 (1), si:dkeyp-63d11.7 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 6 Mapping Details/Browsers

Description:

Predicted to have calcium ion binding activity. Predicted to localize to integral component of membrane. Is expressed in several structures, including axial hypoblast; brain; immature eye; neural tube; and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8).

Genome Resources:

Alliance (1), Gene:557734 (1), Ensembl(GRCz11):ENSDARG00000070074 (1)

GENE EXPRESSION
All Expression Data:	10 figures from 3 publications
Directly Submitted Expression Data:	4 figures (6 images) from Thisse et al., 2004 [IMAGE:7145907]
Wild-type Stages, Structures:	Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	amacrine cell anterior axial hypoblast axial hypoblast cerebellum diencephalon dorsal telencephalon forebrain hindbrain hypothalamus immature eye midbrain ventral region midbrain motor neuron neural tube optic tectum periventricular grey zone neuron rhombomere 2 rhombomere 3 rhombomere 4 rhombomere 5 rhombomere 6 spinal cord tegmentum telencephalon unspecified

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la029218Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa20742	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa20743	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa30873	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa33897	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa33898	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH lrp8 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Myocardial infarction, susceptibility to}	608446

DISEASE ASSOCIATED WITH lrp8 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	biological_process (more)
Cellular Component	integral component of membrane (more)
Molecular Function	calcium ion binding (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	lrp8-201 (1)	8651	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM lrp8 No data available

MARKER RELATIONSHIPS

lrp8 Contained in:	[BAC] DKEY-50M7 (1) (order this), DKEY-61C16 (1) (order this), DKEYP-63D11 (1)
lrp8 Encodes:	[EST] IMAGE:7145907 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001256393 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	RefSeq:NW_018395381 (1)		Blast at MegaBLAST
Polypeptide	UniProtKB:H3K2Y7 (1)	988 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 25)

ORTHOLOGY for lrp8 ( Chr: 6 )

CITATIONS (24)

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