Gene

fermt2

ID

ZDB-GENE-050506-132

Name

FERM domain containing kindlin 2

Symbol

fermt2 Nomenclature History

Previous Names

im:7145859
KIND2 (1)
kindlin-2 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have lipid binding activity. Involved in cell migration; circulatory system development; and cytoskeleton organization. Localizes to intercalated disc. Is expressed in several structures, including forerunner cell group; head mesenchyme; heart; myotome; and notochord. Orthologous to human FERMT2 (fermitin family member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7145859 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fermt2 Human Ortholog

No data available

Associated With fermt2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR019748	FERM central domain
Domain	IPR019749	Band 4.1 domain
Domain	IPR037837	Kindlin/fermitin, PH domain
Domain	IPR040790	Kindlin-2, N-terminal
Family	IPR037843	Kindlin/fermitin
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035963	FERM superfamily, second domain

Domain Details Per Protein

Protein	Length	Band 4.1 domain	FERM central domain	FERM superfamily, second domain	Kindlin-2, N-terminal	Kindlin/fermitin	Kindlin/fermitin, PH domain	PH-like domain superfamily	Pleckstrin homology domain
UniProtKB:A0A2R8RR15 InterPro	688
UniProtKB:A0A2R8QN11 InterPro	695
UniProtKB:A0A8M2B5V7 InterPro	677
UniProtKB:F1Q8X5 InterPro	684

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fermt2-201 (1) Ensembl	Ensembl	2,488 nt	Select Tool
mRNA	fermt2-203 (1) Ensembl	Ensembl	2,430 nt	Select Tool ZFIN BLAST
mRNA	fermt2-204 (1) Ensembl	Ensembl	2,409 nt	Select Tool ZFIN BLAST
ncRNA	fermt2-002 (1) Ensembl	Ensembl	840 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations