Gene

cdc6

ID
ZDB-GENE-050506-131
Name
cell division cycle 6 homolog (S. cerevisiae)
Symbol
cdc6 Nomenclature History
Previous Names
  • im:7145727 (1)
  • zgc:174506
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have DNA replication origin binding activity. Involved in mitotic cell cycle phase transition. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Is expressed in central nervous system and proliferative region. Orthologous to human CDC6 (cell division cycle 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from Yao et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdc6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Meier-Gorlin syndrome 5 Alliance ?Meier-Gorlin syndrome 5 613805
Associated With cdc6 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003593 AAA+ ATPase domain
Domain IPR003959 ATPase, AAA-type, core
Domain IPR015163 Cdc6, C-terminal
Domain IPR041083 AAA lid domain
Family IPR016314 Cell division protein Cdc6/18
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length AAA+ ATPase domain AAA lid domain ATPase, AAA-type, core Cdc6, C-terminal Cell division protein Cdc6/18 P-loop containing nucleoside triphosphate hydrolase Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:A8KC19 561
UniProtKB:F1R1N7 561
UniProtKB:Q7SZP5 588
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations