ZFIN ID: ZDB-GENE-050506-110
Gene Name: RAD50 homolog, double strand break repair protein
Gene Symbol: rad50    Nomenclature History

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Previous Names: im:6906849 (1), si:ch211-79h18.3 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to contribute to 3'-5' exonuclease activity; DNA helicase activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in DNA duplex unwinding; chromosome organization involved in meiotic cell cycle; and telomere maintenance. Predicted to localize to the Mre11 complex and chromosome. Human ortholog(s) of this gene implicated in transitional cell carcinoma. Orthologous to human RAD50 (RAD50 double strand break repair protein).
Genome Resources: Alliance (1),  Gene:553029 (1),  Ensembl(GRCz11):ENSDARG00000038917 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6906849]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH rad50 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Nijmegen breakage syndrome-like disorder 613078
DISEASE ASSOCIATED WITH rad50 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process DNA repair (more)
Cellular Component Mre11 complex (more)
Molecular Function ATPase activity (more)
GO Terms (all 23)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR013134 RAD50, zinc hook
Domain IPR038729 Rad50/SbcC-type AAA domain
Family IPR004584 DNA repair protein Rad50, eukaryotes
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA rad50-201 (1)    Ensembl 4050
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM rad50 No data available
MARKER RELATIONSHIPS
rad50 Contained in: [BAC] CH211-79H18 (1)
rad50 Encodes: [EST] IMAGE:6906849 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_005167938 (1)
Genomic GenBank:CT998556 (1) 134663 nt
Select Tool
Polypeptide UniProtKB:F8W411 (1) 1312 aa
Sequence Information (all 12)
ORTHOLOGY for rad50 ( Chr: 9 )
CITATIONS (22)