ZFIN ID: ZDB-GENE-050428-1
Gene Name: high mobility group box 3a
Gene Symbol: hmgb3a    Nomenclature History

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Previous Names: wu:fb17a03, wu:fk52f12, zgc:162415

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have DNA binding activity, bending and transcription factor binding activity. Predicted to be involved in several processes, including chromatin remodeling; positive regulation of innate immune response; and positive regulation of transcription by RNA polymerase II. Predicted to localize to cytoplasm and nuclear chromatin. Is expressed in several structures, including axis; intermediate cell mass of mesoderm; mesoderm; nervous system; and pectoral fin bud. Human ortholog(s) of this gene implicated in syndromic microphthalmia 13. Orthologous to human HMGB3 (high mobility group box 3).
Genome Resources: Alliance (1),  Gene:561025 (1),  Ensembl(GRCz11):ENSDARG00000056725 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-hmgb3a N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hmgb3a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
syndromic microphthalmia 13 Alliance ?Microphthalmia, syndromic 13 300915
DISEASE ASSOCIATED WITH hmgb3a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process chromatin remodeling (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
aberrant processed transcript hmgb3a-201 (1)    Ensembl 589
mRNA hmgb3a-202 (1)    Ensembl 1709
hmgb3a-204 (1)    Ensembl 837
ncRNA hmgb3a-002 (1)    Ensembl 675
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hmgb3a No data available
MARKER RELATIONSHIPS
hmgb3a Contained in: [BAC] DKEY-6N21 (1) (order this)
hmgb3a Encodes: [EST] fb17a03 (1) (order this), fk52f12, IMAGE:7156270 (1)
[cDNA] MGC:162415 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001122836 (1) 1709 nt
Genomic GenBank:BX005022 (1) 217582 nt Blast at MegaBLAST
Polypeptide UniProtKB:F1QGP8 (1) 213 aa
Sequence Information (all 18)
ORTHOLOGY for hmgb3a ( Chr: 7 )
CITATIONS (23)