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Gene

hcn4

ID
ZDB-GENE-050420-360
Name
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Symbol
hcn4 Nomenclature History
Previous Names
  • si:ch211-203b17.1
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable sodium channel activity and voltage-gated potassium channel activity. Acts upstream of or within heart contraction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in heart primordium and pericardial region. Used to study sick sinus syndrome. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hcn4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Brugada syndrome 8 Alliance Brugada syndrome 8 613123
sick sinus syndrome Alliance Sick sinus syndrome 2 163800
{Epilepsy, idiopathic generalized, susceptibility to, 18} 619521
Associated With hcn4 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018488 Cyclic nucleotide-binding, conserved site
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR005821 Ion transport domain
Domain IPR013621 Ion transport N-terminal
Family IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding-like
Domain Details Per Protein
Protein Length Cyclic nucleotide-binding, conserved site Cyclic nucleotide-binding domain Cyclic nucleotide-binding-like Ion transport domain Ion transport N-terminal Potassium channel, voltage-dependent, EAG/ELK/ERG RmlC-like jelly roll fold
UniProtKB:A0A2R8QRD5 1065
UniProtKB:F6NYL9 1130
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations