ZFIN ID: ZDB-GENE-050420-360
Gene Name: hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Gene Symbol: hcn4    Nomenclature History

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Previous Name: si:ch211-203b17.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have cAMP binding activity and voltage-gated potassium channel activity. Involved in heart contraction. Predicted to localize to integral component of membrane. Is expressed in heart primordium and pericardial region. Used to study sick sinus syndrome. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4).
Genome Resources: Alliance (1),  Gene:557843 (1),  Ensembl(GRCz11):ENSDARG00000061685 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa11188 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39186 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hcn4
    2
    CRISPR2-hcn4
    2
    CRISPR3-hcn4
    2
    CRISPR4-hcn4
    2
    CRISPR5-hcn4
    2
    CRISPR6-hcn4
    2
    CRISPR7-hcn4
    2
    CRISPR8-hcn4
    2
    CRISPR9-hcn4
    2
    CRISPR10-hcn4
    2
    MO1-hcn4 N/A 1
    PHENOTYPE
    Data: Fig. 3 from Jou et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH hcn4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Brugada syndrome 8 Alliance Brugada syndrome 8 613123
    sick sinus syndrome Alliance Sick sinus syndrome 2 163800
    DISEASE ASSOCIATED WITH hcn4 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    sick sinus syndrome twu34Tg + MO1-hcn4 standard conditions Jou et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart contraction (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cAMP binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hcn4-201 (1)    Ensembl 3393
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hcn4 No data available
    MARKER RELATIONSHIPS
    hcn4 Contained in: [BAC] CH211-153O21 (1), CH211-203B17 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_680986 (1) 3886 nt
    Genomic GenBank:BX119923 (1) 159232 nt
    Select Tool
    Polypeptide UniProtKB:F6NYL9 (1) 1130 aa
    Sequence Information (all 8)
    ORTHOLOGY for hcn4 ( Chr: 18 )
    CITATIONS (25)