ZFIN Gene: fgd4a

ZFIN ID: ZDB-GENE-050420-347

ZFIN ID: ZDB-GENE-050420-347

Gene Name:

FYVE, RhoGEF and PH domain containing 4a

Gene Symbol:

fgd4a

Sequence Ontology ID :

SO:0000704

Previous Names:

fgd4, si:ch211-194i18.1, si:dkey-57m7.1

Location:

Chr: 18 Mapping Details/Browsers

Nomenclature History

Note:

This gene has an almost identical sequence to si:dkey-57m7.1. The EST CK683166 matches both.

AUTOMATED DESCRIPTION

Predicted to have Rho guanyl-nucleotide exchange factor activity and metal ion binding activity. Predicted to be involved in regulation of Rho protein signal transduction. Human ortholog(s) of this ...

GENE EXPRESSION
Directly Submitted Expression Data:	4 figures (4 images) from Thisse et al., 2004 [IMAGE:7145382]
Wild-type Stages, Structures:	Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
	basal plate midbrain region diencephalon tegmentum unspecified

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la027904Tg	Transgenic Insertion	Unknown	Unknown	DNA
sa23242	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa23243	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa36587	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa43057	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH fgd4a HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease type 4H	Charcot-Marie-Tooth disease, type 4H	609311

DISEASE ASSOCIATED WITH fgd4a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	regulation of Rho protein signal transduction (more)
Molecular Function	guanyl-nucleotide exchange factor activity (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000219 (1) InterPro:IPR000306 (1) InterPro:IPR001849 (1) InterPro:IPR011993 (1) InterPro:IPR013083 (1) InterPro:IPR017455 (1) InterPro:IPR035899 (1) InterPro:IPR035941 (1) InterPro:IPR037742 (1)	PROSITE:PS50003 (1) PROSITE:PS50010 (1) PROSITE:PS50178 (1)	Pfam:PF00169 (1) Pfam:PF00621 (1) Pfam:PF01363 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	fgd4a-201 (1)	479	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION No description available

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM fgd4a No data available

MARKER RELATIONSHIPS

fgd4aContained in:	[BAC] CH211-136I24 (1) (order this), CH211-194I18 (1) (order this)
fgd4aEncodes:	[EST] IMAGE:7145382 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001177933 (1)	3451bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR293524 (1)	190196bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0R4ILP5 (1)	728aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:158966 (1)

Sequence Information (all 21)

OTHER fgd4a GENE PAGES

Alliance (1)

Gene:556216 (1)

VEGA:OTTDARG00000034660 (1)

Ensembl(GRCz11):ENSDARG00000101471 (1)

ORTHOLOGY for fgd4a (Chr: 18)

CITATIONS (16)

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