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Gene

fgd4a

ID
ZDB-GENE-050420-347
Name
FYVE, RhoGEF and PH domain containing 4a
Symbol
fgd4a Nomenclature History
Previous Names
  • fgd4
  • si:ch211-194i18.1
  • si:dkey-57m7.1
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable guanyl-nucleotide exchange factor activity and metal ion binding activity. Predicted to be involved in cytoskeleton organization and filopodium assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in basal plate midbrain region; diencephalon; and tegmentum. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4).
Genome Resources
Note
This gene has an almost identical sequence to si:dkey-57m7.1. The EST CK683166 matches both.
Comparative Information
Expression
All Expression Data
4 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fgd4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease type 4H Alliance Charcot-Marie-Tooth disease, type 4H 609311
Associated With fgd4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000219 Dbl homology (DH) domain
Domain IPR000306 FYVE zinc finger
Domain IPR001849 Pleckstrin homology domain
Domain IPR017455 Zinc finger, FYVE-related
Domain IPR035941 FGD1-4, C-terminal PH domain
Domain IPR037742 FGD4, N-terminal PH domain
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Domain Details Per Protein
Protein Length Dbl homology (DH) domain Dbl homology (DH) domain superfamily FGD1-4, C-terminal PH domain FGD4, N-terminal PH domain FYVE zinc finger PH-like domain superfamily Pleckstrin homology domain Zinc finger, FYVE-related Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A0R4ILP5 728
UniProtKB:D5FS19 728
UniProtKB:A0A0J9YJA6 25
UniProtKB:F1QAA5 728
UniProtKB:Q1L9G3 565
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations