ZFIN Gene: afdna

ZFIN ID: ZDB-GENE-050419-52

ZFIN ID: ZDB-GENE-050419-52

Gene Name:

afadin, adherens junction formation factor a

Gene Symbol:

afdna Nomenclature History

Previous Names:

mllt4, mllt4a (1), si:ch211-278j12.1

Gene Type:

protein_coding_gene

Location:

Chr: 20 Mapping Details/Browsers

Description:

Predicted to have cell adhesion molecule binding activity. Predicted to be involved in regulation of protein localization. Predicted to localize to adherens junction. Orthologous to human AFDN (afadin, adherens junction formation factor).

Genome Resources:

Alliance (1), Gene:558359 (1), Ensembl(GRCz11):ENSDARG00000029472 (2)

GENE EXPRESSION No data available

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa11340	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this)
sa11351	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa11362	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37138	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37139	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37140	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-afdna		2
CRISPR2-afdna		2
CRISPR3-afdna		2
CRISPR4-afdna		2
CRISPR5-afdna		2
CRISPR6-afdna		2
CRISPR7-afdna		2
CRISPR8-afdna		2
CRISPR9-afdna		2

PHENOTYPE No data available

DISEASE ASSOCIATED WITH afdna HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH afdna VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	signal transduction (more)
Cellular Component	adherens junction (more)
Molecular Function	cell adhesion molecule binding (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	afdna-202 (1)	8628	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM afdna No data available

MARKER RELATIONSHIPS

afdna Contained in:

[BAC] CH211-278J12 (1), DKEY-14A7 (1) (order this), DKEY-286H23 (1) (order this), DKEYP-95D10 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_021468676 (1)		Select Tool ZFIN BLAST NCBI BLAST MegaBLAST Ensembl UCSC BLAT
Genomic	GenBank:AL928920 (1)	195351 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7F4R0 (1)	1976 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 49)

ORTHOLOGY for afdna ( Chr: 20 )

CITATIONS (18)

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