ZFIN ID: ZDB-GENE-050419-45
Gene Name: GDP-mannose 4,6-dehydratase
Gene Symbol: gmds    Nomenclature History

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Previous Names: si:ch211-231n5.3, srn, towhead (1), twd (1), zgc:63772

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits fucosyltransferase activity. Involved in Notch signaling pathway; central nervous system development; and retina layer formation. Predicted to localize to cytoplasm. Is expressed in EVL; corneal epithelium; neuromast; and periderm. Used to study congenital disorder of glycosylation type IIc. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase).
Genome Resources: Alliance (1),  Gene:393461 (1),  Ensembl(GRCz11):ENSDARG00000026629 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021496Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028233Tg Transgenic Insertion Unknown Unknown DNA
    p31erb Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • rw685 Point Mutation Exon 7 Missense ENU
    sa6635 Point Mutation Unknown Premature Stop ENU
    sa6636 Point Mutation Unknown Premature Stop ENU
    sa37043 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43452 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gmds N/A 2
    MO2-gmds N/A 1
    DISEASE ASSOCIATED WITH gmds HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH gmds VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    congenital disorder of glycosylation type IIc gmdsp31erb/p31erb standard conditions Song et al., 2010
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal motor nucleus of vagus nerve development (more)
    Cellular Component cytoplasm (more)
    Molecular Function fucosyltransferase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gmds-003 (1) 886
    gmds-201 (1)    Ensembl 1693
    gmds-203 (1)    Ensembl 2083
    gmds-204 (1)    Ensembl 880
    ottdart00000002404 (1) 509
    ottdart00000002405 (1) 907
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gmds No data available
    MARKER RELATIONSHIPS
    gmds Contained in: [BAC] CH211-231N5 (1), DKEY-100F21 (1) (order this)
    [PAC] BUSM1-84G17 (1)
    gmds Encodes: [cDNA] MGC:63772 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200489 (1) 1134 nt
    Genomic GenBank:BX678772 (1) 112760 nt
    Select Tool
    Polypeptide UniProtKB:A7BI56 (1) 377 aa
    Sequence Information (all 36)
    ORTHOLOGY for gmds ( Chr: 20 )
    CITATIONS (39)