ZFIN ID: ZDB-GENE-050419-192
Gene Name: inositol 1,4,5-trisphosphate receptor, type 2
Gene Symbol: itpr2    Nomenclature History

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Previous Name: si:dkey-196d8.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have anion binding activity; calcium ion binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Predicted to be involved in release of sequestered calcium ion into cytosol. Predicted to localize to several cellular components, including endoplasmic reticulum membrane; sarcoplasmic reticulum; and secretory granule membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2).
Genome Resources: Alliance (1),  Gene:562585 (1),  Ensembl(GRCz11):ENSDARG00000011909 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Ashworth et al., 2007
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Cleavage:64-cell (2.0h-2.25h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013203Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa794 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9038 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10652 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13636 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14152 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23267 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36608 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36609 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39196 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH itpr2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    isolated anhidrosis with normal sweat glands Alliance ?Anhidrosis, isolated, with normal sweat glands 106190
    DISEASE ASSOCIATED WITH itpr2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion transmembrane transport (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function calcium channel activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA itpr2-201 (1)    Ensembl 5841
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM itpr2 No data available
    MARKER RELATIONSHIPS
    itpr2 Contained in: [BAC] CH73-42P23 (1), CH211-204P6 (1), DKEY-196D8 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021467780 (1)
    Genomic GenBank:CR854977 (1) 159813 nt
    Select Tool
    Polypeptide UniProtKB:X1WET6 (1) 2008 aa
    Sequence Information (all 18)
    ORTHOLOGY for itpr2 ( Chr: 18 )
    CITATIONS (27)