Gene

akt3a

ID
ZDB-GENE-050419-180
Name
v-akt murine thymoma viral oncogene homolog 3a
Symbol
akt3a Nomenclature History
Previous Names
  • si:ch211-221n23.2
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma multiforme; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
Fig. S4 from Thyme et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With akt3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 615937
Associated With akt3a Via Experimental Models
Human Disease Fish Conditions Citations
schizophrenia akt3aa229/a229 standard conditions Thyme et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR001849 Pleckstrin homology domain
Domain IPR017892 Protein kinase, C-terminal
Domain IPR034675 Protein kinase B gamma, catalytic domain
Domain IPR039026 Protein Kinase B, pleckstrin homology domain
Family IPR039029 Serine/threonine-protein kinase RAC gamma-like
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal PH-like domain superfamily Pleckstrin homology domain Protein kinase, ATP binding site Protein kinase B gamma, catalytic domain Protein Kinase B, pleckstrin homology domain Protein kinase, C-terminal Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine/threonine-protein kinase RAC gamma-like
UniProtKB:A0A0R4IF30 35
UniProtKB:D9IL79 479
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations