ZFIN ID: ZDB-GENE-050419-180
Gene Name: v-akt murine thymoma viral oncogene homolog 3a
Gene Symbol: akt3a    Nomenclature History

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Previous Name: si:ch211-221n23.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to localize to cytoplasm and nucleus. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma multiforme; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3).
Genome Resources: Alliance (1),  Gene:560549 (1),  Ensembl(GRCz11):ENSDARG00000104810 (1)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a229 Complex Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-akt3a 1
CRISPR2-akt3a 1
CRISPR3-akt3a 1
CRISPR4-akt3a 1
DISEASE ASSOCIATED WITH akt3a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 615937
DISEASE ASSOCIATED WITH akt3a VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
schizophrenia akt3aa229/a229 standard conditions Thyme et al., 2019
GENE ONTOLOGY
Ontology GO Term
Biological Process intracellular signal transduction (more)
Molecular Function ATP binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA akt3a-201 (1)    Ensembl 1147
akt3a-203 (1)    Ensembl 3199
ncRNA akt3a-004 (1)    Ensembl 279
ottdart00000060693 (1)    Ensembl 818
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM akt3a No data available
MARKER RELATIONSHIPS
akt3a Contained in: [BAC] CH73-236I20 (1), CH211-141M16 (1), CH211-221N23 (1)
[Fosmid] CH1073-501O18 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001197201 (1)
Genomic GenBank:CR589882 (1) 205759 nt Blast at MegaBLAST
Polypeptide UniProtKB:D9IL79 (1) 479 aa
Sequence Information (all 18)
ORTHOLOGY for akt3a ( Chr: 13 )
CITATIONS (21)