Gene

ddb2

ID

ZDB-GENE-050419-169

Name

damage-specific DNA binding protein 2

Symbol

ddb2 Nomenclature History

Previous Names

si:dkey-45f10.3

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to contribute to damaged DNA binding activity. Predicted to be involved in DNA repair and response to UV. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group E. Is expressed in central nervous system and neurons. Orthologous to human DDB2 (damage specific DNA binding protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7165203 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ddb2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
xeroderma pigmentosum group E	Alliance	Xeroderma pigmentosum, group E, DDB-negative subtype	278740

Associated With ddb2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Family	IPR033312	DNA damage-binding protein 2
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	DNA damage-binding protein 2	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M9PLU3 InterPro	280
UniProtKB:A0A8M2B5I0 InterPro	351
UniProtKB:Q2YDS1 InterPro PDB	496
UniProtKB:Z4YI04 InterPro	497
UniProtKB:A0A8M2B5L4 InterPro	503

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ddb2-202 (1) Ensembl	Havana	1805 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ddb2-203 (1) Ensembl	Havana	1784 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations