ZFIN ID: ZDB-GENE-050419-169
Gene Name: damage-specific DNA binding protein 2
Gene Symbol: ddb2    Nomenclature History

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Previous Name: si:dkey-45f10.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to contribute to damaged DNA binding activity. Predicted to be involved in DNA repair and response to UV. Predicted to localize to nucleus. Is expressed in central nervous system and neurons. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group E. Orthologous to human DDB2 (damage specific DNA binding protein 2).
Genome Resources: Alliance (1),  Gene:100004133 (1),  Ensembl(GRCz11):ENSDARG00000041140 (1)
GENE EXPRESSION
All Expression Data: 11 figures from 3 publications
Directly Submitted Expression Data: 7 figures (14 images) from Thisse et al., 2004 [IMAGE:7165203]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2975 Point Mutation Unknown Premature Stop ENU
sa18412 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ddb2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    xeroderma pigmentosum group E Alliance Xeroderma pigmentosum, group E, DDB-negative subtype 278740
    DISEASE ASSOCIATED WITH ddb2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to DNA damage stimulus (more)
    Cellular Component Cul4-RING E3 ubiquitin ligase complex (more)
    Molecular Function damaged DNA binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ddb2-202 (1)    Ensembl 1805
    ddb2-203 (1)    Ensembl 1784
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ddb2 No data available
    MARKER RELATIONSHIPS
    ddb2 Contained in: [BAC] DKEY-45F10 (1) (order this)
    ddb2 Encodes: [EST] IMAGE:7165203 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001083061 (1) 1805 nt
    Genomic GenBank:BX942814 (1) 106289 nt
    Select Tool
    Polypeptide UniProtKB:Z4YI04 (1) 497 aa
    Sequence Information (all 20)
    ORTHOLOGY for ddb2 ( Chr: 18 )
    CITATIONS (36)