ZFIN ID: ZDB-GENE-050419-146
Gene Name: basic helix-loop-helix family, member e41
Gene Symbol: bhlhe41    Nomenclature History

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Previous Names: bhlhb3l (1), Dec2 (1), si:ch211-154h20.6

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated; response to cold; and sleep. Predicted to localize to nucleus. Is expressed in several structures, including brain; cardinal system; pleuroperitoneal region; shield; and swim bladder bud. Orthologous to human BHLHE41 (basic helix-loop-helix family member e41).
Genome Resources: Alliance (1),  Gene:563771 (1),  Ensembl(GRCz11):ENSDARG00000041691 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mn0135Gt Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2955 Point Mutation Unknown Splice Site ENU
    sa10095 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-bhlhe41
    2
    MO1-bhlhe41 N/A 1
    PHENOTYPE
    Data: text only from Srdanovic et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH bhlhe41 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    [Short sleep, familial natural, 1] 612975
    DISEASE ASSOCIATED WITH bhlhe41 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bhlhe41-201 (1)    Ensembl 3155
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bhlhe41 No data available
    MARKER RELATIONSHIPS
    bhlhe41 Contained in: [BAC] CH211-154H20 (1)
    bhlhe41 Encodes: [cDNA] MGC:195133 (1), MGC:195162 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001039107 (1) 1505 nt
    Genomic GenBank:BX649507 (1) 166185 nt
    Select Tool
    Polypeptide UniProtKB:Q2PGD2 (1) 421 aa
    Sequence Information (all 19)
    ORTHOLOGY for bhlhe41 ( Chr: 18 )
    CITATIONS (38)