Gene

tsen34

ID

ZDB-GENE-050419-115

Name

TSEN34 tRNA splicing endonuclease subunit

Symbol

tsen34 Nomenclature History

Previous Names

si:ch211-203b8.3

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to localize to tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Orthologous to human TSEN34 (tRNA splicing endonuclease subunit 34).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tsen34 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pontocerebellar hypoplasia type 2C	Alliance	?Pontocerebellar hypoplasia type 2C	612390

Associated With tsen34 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006677	tRNA intron endonuclease, catalytic domain-like
Family	IPR006676	tRNA-splicing endonuclease
Family	IPR016690	tRNA-splicing endonuclease, SEN34 subunit
Homologous_superfamily	IPR011856	tRNA endonuclease-like domain superfamily
Homologous_superfamily	IPR036167	tRNA intron endonuclease, catalytic domain-like superfamily