Gene

rasgrp4

ID
ZDB-GENE-050419-110
Name
RAS guanyl releasing protein 4
Symbol
rasgrp4 Nomenclature History
Previous Names
  • si:dkey-12o15.1
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and guanyl-nucleotide exchange factor activity. Involved in lymph vessel development. Is expressed in caudal vein plexus; dorsal aorta; head; notochord; and posterior cardinal vein. Human ortholog(s) of this gene implicated in immunodeficiency 64. Orthologous to several human genes including RASGRP4 (RAS guanyl releasing protein 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Huang et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from Huang et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rasgrp4 Human Ortholog
No data available
Associated With rasgrp4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Domain IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Domain IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
Domain IPR002048 EF-hand domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR020454 Diacylglycerol/phorbol-ester binding
Family IPR008937 Ras-like guanine nucleotide exchange factor
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR023578 Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
Domain Details Per Protein
Protein Length Diacylglycerol/phorbol-ester binding EF-Hand 1, calcium-binding site EF-hand domain EF-hand domain pair Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Ras guanine-nucleotide exchange factor catalytic domain superfamily Ras guanine nucleotide exchange factor domain superfamily Ras guanine-nucleotide exchange factors catalytic domain Ras-like guanine nucleotide exchange factor Ras-like guanine nucleotide exchange factor, N-terminal
UniProtKB:Q1L9A0 687
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations