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ZIRC
ZFIN ID: ZDB-GENE-050417-95
Gene Name: HRas proto-oncogene, GTPase a
Gene Symbol: hrasa    Nomenclature History

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Previous Names: hras, xRAS1 (1), sb:eu826, zgc:110250 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; autoimmune hepatitis; carcinoma (multiple); and epidermal nevus. Is expressed in basal plate midbrain region; nervous system; and trigeminal placode. Orthologous to human HRAS (HRas proto-oncogene, GTPase).
Genome Resources: Alliance (1),  Gene:550286 (1),  Ensembl(GRCz11):ENSDARG00000098497 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hrasa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Costello syndrome Alliance Congenital myopathy with excess of muscle spindles 218040
Costello syndrome 218040
epidermal nevus Alliance Nevus sebaceous or woolly hair nevus, somatic 162900
large congenital melanocytic nevus Alliance Spitz nevus or nevus spilus, somatic 137550
linear nevus sebaceous syndrome Alliance Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic 163200
thyroid gland follicular carcinoma Alliance Thyroid carcinoma, follicular, somatic 188470
urinary bladder cancer Alliance Bladder cancer, somatic 109800
DISEASE ASSOCIATED WITH hrasa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process signal transduction (more)
Cellular Component membrane (more)
Molecular Function GTPase activity (more)
GO Terms (all 8)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA hrasa-201 (1)    Ensembl 1526
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hrasa No data available
MARKER RELATIONSHIPS
hrasa Contained in: [BAC] CH211-103E16 (1) (order this)
hrasa Encodes: [EST] eu826 (1)
[cDNA] MGC:110250 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001017623 (1) 1436 bp
Genomic GenBank:BX323801 (1) 181565 bp
Select Tool
Polypeptide UniProtKB:F1QNG4 (1) 189 aa
Sequence Clusters UniGene:151909 (1)
Sequence Information (all 12)
ORTHOLOGY for hrasa ( Chr: 25 )
CITATIONS (26)