ZFIN ID: ZDB-GENE-050417-90
Gene Name: isoprenylcysteine carboxyl methyltransferase
Gene Symbol: icmt    Nomenclature History

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Previous Names: im:6895697, zgc:110258

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Predicted to be involved in C-terminal protein methylation. Predicted to localize to endoplasmic reticulum. Is expressed in liver and yolk syncytial layer. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase).
Genome Resources: Alliance (1),  Gene:550281 (1),  Ensembl(GRCz11):ENSDARG00000020241 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 7 figures (9 images) from Thisse et al., 2004 [IMAGE:6895697]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7165233]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014352Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43967 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH icmt HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH icmt VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process C-terminal protein methylation (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function methyltransferase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA icmt-201 (1)    Ensembl 2210
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM icmt No data available
    MARKER RELATIONSHIPS
    icmt Contained in: [BAC] DKEY-1C11 (order this)
    icmt Encodes: [EST] IMAGE:6895697 (1), IMAGE:7165233 (1)
    [cDNA] MGC:110258 (1), MGC:192019 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001017618 (1) 1677 nt
    Genomic GenBank:CR847529 (1) 158776 nt
    Select Tool
    Polypeptide UniProtKB:F1R5J9 (1) 292 aa
    Sequence Information (all 15)
    ORTHOLOGY for icmt ( Chr: 23 )
    CITATIONS (25)