Gene

pfklb

ID

ZDB-GENE-050417-62

Name

phosphofructokinase, liver b

Symbol

pfklb Nomenclature History

Previous Names

zgc:110298 (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have several functions, including 6-phosphofructokinase activity; adenyl ribonucleotide binding activity; and fructose-6-phosphate binding activity. Predicted to be involved in several processes, including canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and protein homotetramerization. Predicted to localize to 6-phosphofructokinase complex and membrane. Is expressed in liver; male organism; nervous system; somite; and yolk syncytial layer. Orthologous to human PFKL (phosphofructokinase, liver type).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:110298 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pfklb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hemolytic anemia due to phosphofructokinase deficiency

Associated With pfklb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR015912	Phosphofructokinase, conserved site
Domain	IPR000023	Phosphofructokinase domain
Family	IPR009161	ATP-dependent 6-phosphofructokinase, eukaryotic-type
Family	IPR022953	ATP-dependent 6-phosphofructokinase
Family	IPR041914	ATP-dependent 6-phosphofructokinase, vertebrate-type
Homologous_superfamily	IPR035966	Phosphofructokinase superfamily

Domain Details Per Protein

Protein	Length	ATP-dependent 6-phosphofructokinase	ATP-dependent 6-phosphofructokinase, eukaryotic-type	ATP-dependent 6-phosphofructokinase, vertebrate-type	Phosphofructokinase, conserved site	Phosphofructokinase domain	Phosphofructokinase superfamily
UniProtKB:A0A0R4ID68 InterPro	779

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations