ZFIN ID: ZDB-GENE-050417-406
Gene Name: protein phosphatase 3, catalytic subunit, beta isozyme
Gene Symbol: ppp3cb    Nomenclature History

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Previous Names: wu:fq19c08, zgc:110141

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-NFAT signaling cascade. Predicted to localize to the calcineurin complex and cytosol. Human ortholog(s) of this gene implicated in infantile or early childhood epileptic encephalopathy 1. Is expressed in hatching gland; integument; nervous system; and pharyngeal arch. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha).
Genome Resources: Alliance (1),  Gene:550554 (1),  Ensembl(GRCz11):ENSDARG00000025106 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ppp3cb HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH ppp3cb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process calcineurin-mediated signaling (more)
Cellular Component calcineurin complex (more)
Molecular Function hydrolase activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
Domain IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Domain IPR041751 PP2B, metallophosphatase domain
Homologous_superfamily IPR029052 Metallo-dependent phosphatase-like
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ppp3cb-201 (1)    Ensembl 3158
ppp3cb-202 (1)    Ensembl 992
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ppp3cb No data available
MARKER RELATIONSHIPS
ppp3cb Contained in: [BAC] CH73-168C14 (1), CH73-345I5 (1)
ppp3cb Encodes: [EST] fq19c08 (1) (order this)
[cDNA] MGC:110141 (1), MGC:192474 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001017856 (1) 2123 nt
Genomic GenBank:FP017217 (1) 119011 nt
Select Tool
Polypeptide UniProtKB:B2GS58 (1) 511 aa
Sequence Information (all 26)
ORTHOLOGY for ppp3cb ( Chr: 14 )
CITATIONS (21)