Gene
mecr
- ID
- ZDB-GENE-050417-399
- Name
- mitochondrial trans-2-enoyl-CoA reductase
- Symbol
- mecr Nomenclature History
- Previous Names
-
- zgc:110153 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity. Predicted to be involved in fatty acid metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7156062 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| childhood-onset dystonia with optic atrophy and basal ganglia abnormalities | Alliance | Dystonia, childhood-onset, with optic atrophy and basal ganglia abnormalities | 617282 |
| Optic atrophy 16 | 620629 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013149 | Alcohol dehydrogenase-like, C-terminal |
| Domain | IPR013154 | Alcohol dehydrogenase-like, N-terminal |
| Family | IPR051034 | Mitochondrial Enoyl-ACP Reductase |
| Homologous_superfamily | IPR011032 | GroES-like superfamily |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alcohol dehydrogenase-like, C-terminal | Alcohol dehydrogenase-like, N-terminal | GroES-like superfamily | Mitochondrial Enoyl-ACP Reductase | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9P7W8 | InterPro | 190 | |||||
| UniProtKB:Q6GQN8 | InterPro | 377 | |||||
| UniProtKB:Q568Q9 | InterPro | 377 | |||||
| UniProtKB:A0A8M9NZ96 | InterPro | 263 |
Interactions and Pathways
No data available
Plasmids
No data available