Gene

nfu1

ID
ZDB-GENE-050417-365
Name
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
Symbol
nfu1 Nomenclature History
Previous Names
  • HIRA interacting protein 5
  • hirip5 (1)
  • zgc:109711
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have 4 iron, 4 sulfur cluster binding activity and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nfu1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
multiple mitochondrial dysfunctions syndrome 1 Alliance Multiple mitochondrial dysfunctions syndrome 1 605711
Spastic paraplegia 93, autosomal recessive 620938
Associated With nfu1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001075 NIF system FeS cluster assembly, NifU, C-terminal
Domain IPR014824 Scaffold protein Nfu/NifU, N-terminal
Family IPR035433 NFU1-like
Homologous_superfamily IPR034904 Fe-S cluster assembly domain superfamily
Homologous_superfamily IPR036498 Scaffold protein Nfu/NifU, N-terminal domain superfamily
Domain Details Per Protein
Protein Length Fe-S cluster assembly domain superfamily NFU1-like NIF system FeS cluster assembly, NifU, C-terminal Scaffold protein Nfu/NifU, N-terminal Scaffold protein Nfu/NifU, N-terminal domain superfamily
UniProtKB:B0S8L0 243
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations