ZFIN ID: ZDB-GENE-050417-365
Gene Name: NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
Gene Symbol: nfu1    Nomenclature History

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Previous Names: HIRA interacting protein 5, hirip5 (1), zgc:109711

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have 4 iron, 4 sulfur cluster binding activity and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold).
Genome Resources: Alliance (1),  Gene:403053 (1),  Ensembl(GRCz11):ENSDARG00000068125 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:109711]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa38712 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nfu1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    multiple mitochondrial dysfunctions syndrome 1 Alliance Multiple mitochondrial dysfunctions syndrome 1 605711
    DISEASE ASSOCIATED WITH nfu1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process iron-sulfur cluster assembly (more)
    Cellular Component mitochondrion (more)
    Molecular Function iron ion binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nfu1-201 (1)    Ensembl 1651
    ncRNA nfu1-002 (1)    Ensembl 812
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nfu1 No data available
    MARKER RELATIONSHIPS
    nfu1 Contained in: [BAC] CH211-120B19 (1)
    nfu1 Encodes: [cDNA] MGC:109711 (1), MGC:173664 (1), MGC:192272 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001122708 (1) 1651 nt
    Genomic GenBank:BX957316 (1) 144967 nt
    Select Tool
    Polypeptide UniProtKB:B0S8L0 (1) 243 aa
    Sequence Information (all 21)
    ORTHOLOGY for nfu1 ( Chr: 8 )
    CITATIONS (23)