ZFIN ID: ZDB-GENE-050417-361
Gene Name: phytanoyl-CoA 2-hydroxylase
Gene Symbol: phyh    Nomenclature History

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Previous Name: zgc:110203

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have phytanoyl-CoA dioxygenase activity. Predicted to be involved in fatty acid alpha-oxidation. Is expressed in intestinal bulb and liver. Human ortholog(s) of this gene implicated in Refsum disease; Zellweger syndrome; orofacial cleft; and peroxisomal disease. Orthologous to human PHYH (phytanoyl-CoA 2-hydroxylase).
Genome Resources: Alliance (1),  Gene:550521 (1),  Ensembl(GRCz11):ENSDARG00000086740 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 7 figures (6 images) from Thisse et al., 2004 [MGC:110203]
Wild-type Stages, Structures: Pharyngula:High-pec (42.0h-48.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024744Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH phyh HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Refsum disease Alliance Refsum disease 266500
    DISEASE ASSOCIATED WITH phyh VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fatty acid alpha-oxidation (more)
    Molecular Function phytanoyl-CoA dioxygenase activity (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA phyh-201 (1)    Ensembl 2995
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM phyh No data available
    MARKER RELATIONSHIPS
    phyh Contained in: [BAC] CH211-206K18 (1)
    [Fosmid] CH1073-67J19 (1)
    phyh Encodes: [cDNA] MGC:110203 (1), MGC:191542 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001017823 (1) 1944 nt
    Genomic GenBank:BX323869 (1) 53128 nt
    Select Tool
    Polypeptide UniProtKB:E7FCS1 (1) 335 aa
    Sequence Information (all 14)
    ORTHOLOGY for phyh ( Chr: 4 )
    CITATIONS (19)