ZFIN ID: ZDB-GENE-050417-357
Gene Name: twist family bHLH transcription factor 1b
Gene Symbol: twist1b
Sequence Ontology ID : SO:0000704

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Previous Names: twist1a (2), zgc:110208 (1)

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(Including Attributions)
Location: Chr: 16 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits enhancer sequence-specific DNA binding activity; involved in several processes, including dorsal/ventral pattern formation, pharyngeal system development, and regulation of bone  ...
GENE EXPRESSION
All Expression Data: 20 figures from 12 publications
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el570 Small Deletion Unknown Unknown TALEN
sh423 Small Deletion Unknown Frameshift, Premature Stop CRISPR
Targeting reagents:
PHENOTYPE
Data: Fig. 4 from Yang et al., 2011
Observed in:
DISEASE ASSOCIATED WITH twist1b HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
craniosynostosis Craniosynostosis 1 123100
Saethre-Chotzen syndrome Saethre-Chotzen syndrome with or without eyelid anomalies 101400
Sweeney-Cox syndrome 617746
Sweeney-Cox syndrome 617746
Robinow-Sorauf syndrome 180750
DISEASE ASSOCIATED WITH twist1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process dorsal/ventral pattern formation (more)
Molecular Function enhancer sequence-specific DNA binding (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011598 (1)
  • InterPro:IPR015789 (1)
  • InterPro:IPR036638 (1)
  • PROSITE:PS50888 (1)
  • Pfam:PF00010 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA twist1b-201 (1) 1215
    twist1b-202 (1) 944
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM twist1b
    MARKER RELATIONSHIPS
    twist1bContained in: [BAC] CH73-181M7 (1) (order this), DKEY-10F11 (order this)
    twist1bEncodes: [cDNA] MGC:110208 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001017820 (1) 1226bp
    Genomic GenBank:BX005389 (1) 221363bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q568M7 (1) 169aa
    Sequence Clusters UniGene:90894 (1)
    Sequence Information (all 17)
    OTHER twist1b GENE PAGES
  • Alliance (1)
  • Gene:550518 (1)
  • VEGA:OTTDARG00000036466 (1)
  • Ensembl(GRCz11):ENSDARG00000076010 (2)
  • ORTHOLOGY for twist1b (Chr: 16)
    CITATIONS (38)