ZFIN ID: ZDB-GENE-050417-352
Gene Name: RAS related 2
Gene Symbol: rras2    Nomenclature History

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Previous Names: wu:fc47b08, zgc:110215

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to localize to plasma membrane. Is expressed in several structures, including adaxial cell; head mesenchyme; hindbrain neural plate; musculature system; and notochord. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human RRAS2 (RAS related 2).
Genome Resources: Alliance (1),  Gene:550513 (1),  Ensembl(GRCz11):ENSDARG00000036252 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34081 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34082 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rras2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Noonan syndrome 12 618624
    Ovarian carcinoma
    DISEASE ASSOCIATED WITH rras2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process signal transduction (more)
    Cellular Component membrane (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rras2-201 (1)    Ensembl 4712
    ncRNA rras2-002 (1) 274
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rras2 No data available
    MARKER RELATIONSHIPS
    rras2 Contained in: [BAC] CH211-77A11 (1)
    rras2 Encodes: [EST] fc47b08 (1), fc73d03 (1), fc73d09 (1)
    [cDNA] MGC:110215 (1), MGC:192357 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001017815 (1) 1568 nt
    Genomic GenBank:BX005056 (1) 173708 nt
    Select Tool
    Polypeptide UniProtKB:Q568M0 (1) 202 aa
    Sequence Information (all 17)
    ORTHOLOGY for rras2 ( Chr: 7 )
    CITATIONS (20)