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General Information
ZIRC
ZFIN ID: ZDB-GENE-050417-343
Gene Name: 3-hydroxybutyrate dehydrogenase, type 2
Gene Symbol: bdh2    Nomenclature History

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Previous Name: zgc:110323

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have 3-hydroxybutyrate dehydrogenase activity and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Involved in erythrocyte maturation; heme metabolic process; and hemoglobin biosynthetic process. Predicted to localize to the cytoplasm. Orthologous to human BDH2 (3-hydroxybutyrate dehydrogenase 2).
Genome Resources: Alliance (1),  Gene:550507 (1),  Ensembl(GRCz11):ENSDARG00000052696 (2)
GENE EXPRESSION
All Expression Data: Fig. S6 from Devireddy et al., 2010
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa32733 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39663 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39664 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45080 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bdh2 N/A 2
    MO2-bdh2 N/A 1
    DISEASE ASSOCIATED WITH bdh2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH bdh2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process erythrocyte maturation (more)
    Cellular Component cytoplasm (more)
    Molecular Function oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002347 (1)
  • InterPro:IPR020904 (1)
  • InterPro:IPR036291 (1)
  • PROSITE:PS00061 (1)
  • EC:1.1.1.30 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bdh2-201 (1)    Ensembl 1061
    bdh2-202 (1)    Ensembl 1016
    bdh2-203 (1)    Ensembl 854
    ncRNA bdh2-004 (1)    Ensembl 534
    bdh2-005 (1)    Ensembl 787
    bdh2-006 (1)    Ensembl 492
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bdh2 No data available
    MARKER RELATIONSHIPS
    bdh2 Contained in: [BAC] DKEY-162B23 (1) (order this)
    bdh2 Encodes: [cDNA] MGC:110323 (1) (order this), MGC:192525 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001017809 (1) 1099 bp
    Genomic GenBank:CR388005 (1) 197480 bp
    Select Tool
    Polypeptide UniProtKB:B2GSA5 (1) 245 aa
    Sequence Clusters UniGene:84969 (1)
    Sequence Information (all 20)
    ORTHOLOGY for bdh2 ( Chr: 1 )
    CITATIONS (23)