header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-050417-267
Gene Name: actin alpha 1, skeletal muscle a
Gene Symbol: acta1a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: hm:zeh0293, zeh0293, zgc:112098

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have ATP binding activity. Involved in skeletal muscle fiber development. Predicted to localize to several cellular components, including the cell body; filopodium; and lamellipodium. Human ortholog(s) of this gene implicated in nemaline myopathy 3. Is expressed in several structures, including adaxial cell; fin; musculature system; pericardial region; and trunk. Orthologous to human ACTA1 (actin alpha 1, skeletal muscle).
Genome Resources: Alliance (1),  Gene:550445 (1),  Ensembl(GRCz11):ENSDARG00000036371 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9336 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18713 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19610 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko1075b Indel Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-acta1a 1
    CRISPR2-acta1a
    2
    CRISPR3-acta1a
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH acta1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital fiber-type disproportion Alliance Myopathy, congenital, with fiber-type disproportion 1 255310
    nemaline myopathy 3 Alliance Myopathy, actin, congenital, with cores 161800
    Myopathy, actin, congenital, with excess of thin myofilaments 161800
    Nemaline myopathy 3, autosomal dominant or recessive 161800
    ?Myopathy, scapulohumeroperoneal 616852
    DISEASE ASSOCIATED WITH acta1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process skeletal muscle fiber development (more)
    Cellular Component cell body (more)
    Molecular Function ATP binding (more)
    GO Terms (all 11)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA acta1a-201 (1)    Ensembl 1612
    ncRNA acta1a-002 (1)    Ensembl 557
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acta1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(acta1a:stac3-EGFP) acta1a EGFPstac3 Danio rerio 1 2
    MARKER RELATIONSHIPS
    acta1a Contained in: [BAC] CH211-133L11 (1) (order this)
    acta1a Encodes: [EST] fb19e10 (1) (order this), zeh0293
    [cDNA] MGC:112098 (1) (order this), MGC:191650 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001017750 (1) 1600 bp
    Genomic GenBank:AL929114 (1) 180158 bp
    Select Tool
    Polypeptide UniProtKB:F1QUN8 (1) 377 aa
    Sequence Clusters UniGene:75118 (1)
    Sequence Information (all 16)
    ORTHOLOGY for acta1a ( Chr: 1 )
    CITATIONS (45)