Gene

unc45a

ID

ZDB-GENE-050417-158

Name

unc-45 myosin chaperone A

Symbol

unc45a Nomenclature History

Previous Names

kurzschluss (1)
kus (1)
zgc:112031 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable Hsp90 protein binding activity. Acts upstream of or within angiogenesis; blood circulation; and cartilage development. Is expressed in brain; digestive system; head; polster; and presumptive neural retina. Orthologous to human UNC45A (unc-45 myosin chaperone A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UCSC scRNA-seq

Thisse Expression Data

IMAGE:7157819 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With unc45a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Osteootohepatoenteric syndrome	619377

Associated With unc45a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013026	Tetratricopeptide repeat-containing domain
Domain	IPR024660	UNC-45/Cro1/She4, central domain
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Repeat	IPR000225	Armadillo
Repeat	IPR019734	Tetratricopeptide repeat

Domain Details Per Protein

Protein	Length	Armadillo	Armadillo-like helical	Armadillo-type fold	Tetratricopeptide-like helical domain superfamily	Tetratricopeptide repeat	Tetratricopeptide repeat-containing domain	UNC-45/Cro1/She4, central domain
UniProtKB:Q567I0 InterPro	218
UniProtKB:B2B9A8 InterPro	935
UniProtKB:F1QU23 InterPro	935
UniProtKB:A0A0R4IU52 InterPro	230

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
aberrant processed transcript	unc45a-201 (1) Ensembl	3313 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	unc45a-205 (1) Ensembl	997 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	unc45a-003 (1) Ensembl	675 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations