Gene
alad
- ID
- ZDB-GENE-050417-123
- Name
- aminolevulinate dehydratase
- Symbol
- alad Nomenclature History
- Previous Names
-
- zgc:110219 (1)
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have porphobilinogen synthase activity and zinc ion binding activity. Predicted to be involved in heme biosynthetic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Is expressed in blood and ventral mesoderm. Orthologous to human ALAD (aminolevulinate dehydratase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110219 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute porphyria | Alliance | Porphyria, acute hepatic | 612740 |
| acute porphyria | Alliance | {Lead poisoning, susceptibility to} | 612740 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Aldolase-type TIM barrel | Delta-aminolevulinic acid dehydratase | Delta-aminolevulinic acid dehydratase, active site |
|---|---|---|---|---|
|
UniProtKB:Q568L9
|
331 |
Interactions and Pathways
No data available
Plasmids
No data available