ZFIN ID: ZDB-GENE-050417-123
Gene Name: aminolevulinate dehydratase
Gene Symbol: alad    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: zgc:110219 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have porphobilinogen synthase activity and zinc ion binding activity. Predicted to be involved in heme biosynthetic process. Predicted to localize to cytosol. Is expressed in blood and ventral mesoderm. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase).
Genome Resources: Alliance (1),  Gene:550338 (1),  Ensembl(GRCz11):ENSDARG00000100372 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2004 [MGC:110219]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20556 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sus003 Small Deletion Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-alad N/A 1
    TALEN1-alad 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH alad HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute porphyria Alliance Porphyria, acute hepatic 612740
    {Lead poisoning, susceptibility to} 612740
    DISEASE ASSOCIATED WITH alad VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process porphyrin-containing compound biosynthetic process (more)
    Cellular Component cytosol (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA alad-201 (1)    Ensembl 1658
    ncRNA alad-002 (1)    Ensembl 115
    alad-003 (1)    Ensembl 800
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alad No data available
    MARKER RELATIONSHIPS
    alad Contained in: [BAC] CH73-203I15 (1)
    alad Encodes: [cDNA] MGC:110219 (1), MGC:191538 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001017645 (1) 1388 nt
    Genomic GenBank:CU468929 (1) 104293 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IPV1 (1) 331 aa
    Sequence Information (all 12)
    ORTHOLOGY for alad ( Chr: 5 )
    CITATIONS (26)