Gene

prkn

ID
ZDB-GENE-050417-109
Name
parkin RBR E3 ubiquitin protein ligase
Symbol
prkn Nomenclature History
Previous Names
  • park2 (1)
  • parkin (2)
  • si:ch211-123f21.1
  • zgc:112390 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in several processes, including mitochondrial electron transport, NADH to ubiquinone; protein autoubiquitination; and response to temperature stimulus. Localizes to cytoplasm. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; and ovarian cancer. Is expressed in digestive system; gill; heart; muscle; and nervous system. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Flinn et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkn Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lung cancer Alliance Adenocarcinoma of lung, somatic 211980
ovarian cancer Alliance Ovarian cancer, somatic 167000
Parkinson's disease 2 Alliance Parkinson disease, juvenile, type 2 600116
Associated With prkn Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000626 Ubiquitin-like domain
Domain IPR002867 IBR domain
Domain IPR041170 RING/Ubox-like zinc-binding domain
Domain IPR041565 Parkin, RING/Ubox like zinc-binding domain
Domain IPR044066 TRIAD supradomain
Family IPR003977 E3 ubiquitin-protein ligase parkin
Family IPR031127 E3 ubiquitin ligase RBR family
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Domain Details Per Protein
Protein Length E3 ubiquitin ligase RBR family E3 ubiquitin-protein ligase parkin IBR domain Parkin, RING/Ubox like zinc-binding domain RING/Ubox-like zinc-binding domain TRIAD supradomain Ubiquitin-like domain Ubiquitin-like domain superfamily
UniProtKB:Q561U2 458
UniProtKB:A0A0H2UKX4 458
UniProtKB:F1Q9C4 176
UniProtKB:A5WUG4 57
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations