ZFIN ID: ZDB-GENE-050414-2
Gene Name: eukaryotic translation initiation factor 2-alpha kinase 3
Gene Symbol: eif2ak3
Sequence Ontology ID : SO:0000704

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Attributions

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Previous Names: PEK (1), PERK (1), zgc:152949

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(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have eukaryotic translation initiation factor 2alpha kinase activity; involved in response to hypoxia; predicted to localize to the cytosolic ribosome; orthologous to human EIF2AK3  ...
GENE EXPRESSION
All Expression Data: 6 figures from 7 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
it312 Small Deletion Exon 13 Frameshift CRISPR
la018397Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa451 Point Mutation Unknown Splice Site ENU
    sa4496 Point Mutation Unknown Splice Site ENU
    sa42159 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH eif2ak3 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Wolcott-Rallison syndrome Wolcott-Rallison syndrome 226980
    DISEASE ASSOCIATED WITH eif2ak3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to hypoxia (more)
    Cellular Component cellular_component (more)
    Molecular Function ATP binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR011047 (1)
  • InterPro:IPR015943 (1)
  • InterPro:IPR017441 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00069 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA eif2ak3-002 (1) 1679
    eif2ak3-003 (1) 580
    mRNA eif2ak3-202 (1) 3970
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM eif2ak3 No data available
    MARKER RELATIONSHIPS
    eif2ak3Contained in: [BAC] DKEY-12J14 (1) (order this)
    eif2ak3Encodes: [cDNA] MGC:152949 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005156585 (1)
    Genomic GenBank:CR388098 (1) 192818bp
    Select Tool
    Polypeptide UniProtKB:B8JI14 (1) 1099aa
    Sequence Clusters UniGene:85007 (1)
    Sequence Information (all 21)
    OTHER eif2ak3 GENE PAGES
  • Alliance (1)
  • Gene:559564 (1)
  • VEGA:OTTDARG00000027812 (1)
  • Ensembl(GRCz11):ENSDARG00000062139 (2)
  • ORTHOLOGY for eif2ak3 (Chr: 13)
    CITATIONS (45)