Gene

st3gal3b

ID

ZDB-GENE-050411-13

Name

ST3 beta-galactoside alpha-2,3-sialyltransferase 3b

Symbol

st3gal3b Nomenclature History

Previous Names

SIAT6 (1)
st3gal3-r1 (1)
st3gal3l
im:6892850

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have N-acetyllactosaminide alpha-2,3-sialyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to localize to Golgi apparatus and integral component of membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and early infantile epileptic encephalopathy 15. Is expressed in several structures, including cardiovascular system; corpuscles of Stannius; hypochord; pleuroperitoneal region; and ventral mesoderm. Orthologous to human ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:6892850 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With st3gal3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 12	Alliance	Intellectual developmental disorder, autosomal recessive 12	611090
developmental and epileptic encephalopathy 15	Alliance	Developmental and epileptic encephalopathy 15	615006

Associated With st3gal3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001675	Glycosyl transferase family 29
Family	IPR012163	Sialyltransferase
Homologous_superfamily	IPR038578	GT29-like superfamiliy

Domain Details Per Protein

Protein	Length	Glycosyl transferase family 29	GT29-like superfamiliy	Sialyltransferase
UniProtKB:Q702R8 InterPro	355
UniProtKB:A0A8M2BAD2 InterPro	372
UniProtKB:A0A8M9Q7C0 InterPro	396
UniProtKB:E7FBG1 InterPro	356

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	st3gal3b-204 (1) Ensembl	Havana	926 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	st3gal3b-205 (1) Ensembl	Havana	2068 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	st3gal3b-002 (1) Ensembl	Havana	556 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	st3gal3b-003 (1) Ensembl	Havana	518 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations