Gene
nr1h3
- ID
- ZDB-GENE-050410-7
- Name
- nuclear receptor subfamily 1, group H, member 3
- Symbol
- nr1h3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Exhibits nuclear receptor activity. Involved in several processes, including embryonic viscerocranium morphogenesis; lipid homeostasis; and regulation of intestinal lipid absorption. Predicted to localize to RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Is expressed in several structures, including brain; digestive system; eye; heart; and pleuroperitoneal region. Orthologous to several human genes including NR1H3 (nuclear receptor subfamily 1 group H member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113339 (7 images)
- IMAGE:7141239 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR023257 | Liver X receptor |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Liver X receptor | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IVP0
|
441 |
Interactions and Pathways
Plasmids
No data available