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General Information
ZIRC
ZFIN ID: ZDB-GENE-050410-7
Gene Name: nuclear receptor subfamily 1, group H, member 3
Gene Symbol: nr1h3    Nomenclature History

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Previous Names: im:7141239, lxr (1), LXRalpha (1), wu:fd59b01, zgc:113339, zgc:158542

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits nuclear receptor activity. Involved in several processes, including embryonic viscerocranium morphogenesis; lipid homeostasis; and regulation of intestinal lipid absorption. Predicted to localize to the RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Is expressed in several structures, including brain; digestive system; eye; heart; and pleuroperitoneal region. Orthologous to several human genes including NR1H3 (nuclear receptor subfamily 1 group H member 3).
Genome Resources: Alliance (1),  Gene:548341 (1),  Ensembl(GRCz11):ENSDARG00000098439 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb266 Small Deletion Exon 4 Unknown CRISPR
ihb267 Indel Unknown Unknown CRISPR
z101a Small Deletion Unknown Premature Stop TALEN
z102a Indel Unknown Premature Stop TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-nr1h3 1
MO1-nr1h3 N/A 3
MO2-nr1h3 N/A 1
TALEN1-nr1h3 1
DISEASE ASSOCIATED WITH nr1h3 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH nr1h3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of transcription by RNA polymerase II (more)
Cellular Component nucleus (more)
Molecular Function DNA-binding transcription factor activity (more)
GO Terms (all 30)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nr1h3-202 (1)    Ensembl 4969
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nr1h3
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(actb2:EGFP-nr1h3) actb2 EGFPnr1h3 Danio rerio 1 3
Tg(fabp2:EGFP-nr1h3) fabp2 EGFPnr1h3 Danio rerio 1 4
MARKER RELATIONSHIPS
nr1h3 Contained in: [BAC] CH73-223J12 (1) (order this)
nr1h3 Encodes: [EST] fd59b01, IMAGE:7141239 (1) (order this)
[cDNA] MGC:113339 (1) (order this), MGC:158542 (1) (order this), MGC:191690 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001017545 (1) 3515 bp
Genomic GenBank:FO704901 (1) 38936 bp
Select Tool
Polypeptide UniProtKB:A0A0R4IVP0 (1) 441 aa
Sequence Clusters UniGene:29884 (1)
Sequence Information (all 23)
ORTHOLOGY for nr1h3 ( Chr: 7 )
CITATIONS (45)