Gene

trim2a

ID
ZDB-GENE-050327-99
Name
tripartite motif containing 2a
Symbol
trim2a Nomenclature History
Previous Names
  • trim2 (1)
  • zgc:113099
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within myeloid cell differentiation and primitive hemopoiesis. Predicted to be located in cytoplasm. Is expressed in blood cell and vascular endothelium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Cannon et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Cannon et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With trim2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease type 2R Alliance Charcot-Marie-Tooth disease, type 2R 615490
Associated With trim2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017907 Zinc finger, RING-type, conserved site
Domain IPR000315 B-box-type zinc finger
Domain IPR001841 Zinc finger, RING-type
Domain IPR003649 B-box, C-terminal
Domain IPR027370 RING-type zinc-finger, LisH dimerisation motif
Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014756 Immunoglobulin E-set
Repeat IPR001258 NHL repeat
Repeat IPR001298 Filamin/ABP280 repeat
Repeat IPR013017 NHL repeat, subgroup
Repeat IPR017868 Filamin/ABP280 repeat-like
Domain Details Per Protein
Protein Length B-box, C-terminal B-box-type zinc finger Filamin/ABP280 repeat Filamin/ABP280 repeat-like Immunoglobulin E-set Immunoglobulin-like fold NHL repeat NHL repeat, subgroup RING-type zinc-finger, LisH dimerisation motif Six-bladed beta-propeller, TolB-like Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type Zinc finger, RING-type, conserved site
UniProtKB:Q58ER5 744
UniProtKB:F1QFW2 744
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations