Gene
mocos
- ID
- ZDB-GENE-050327-94
- Name
- molybdenum cofactor sulfurase
- Symbol
- mocos Nomenclature History
- Previous Names
-
- im:7142948
- zgc:110784 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable molybdenum cofactor sulfurtransferase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Is expressed in neural crest. Human ortholog(s) of this gene implicated in xanthinuria type II. Orthologous to human MOCOS (molybdenum cofactor sulfurase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7142948 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| xanthinuria type II | Alliance | Xanthinuria, type II | 603592 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000192 | Aminotransferase class V domain |
| Domain | IPR005302 | Molybdenum cofactor sulfurase, C-terminal |
| Domain | IPR005303 | Molybdenum cofactor sulfurase, middle domain |
| Family | IPR028886 | Molybdenum cofactor sulfurase |
| Homologous_superfamily | IPR011037 | Pyruvate kinase-like, insert domain superfamily |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminotransferase class V domain | Molybdenum cofactor sulfurase | Molybdenum cofactor sulfurase, C-terminal | Molybdenum cofactor sulfurase, middle domain | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain | Pyruvate kinase-like, insert domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1N4Y2 | InterPro | 851 | ||||||||
| UniProtKB:A0A8M3B7X2 | InterPro | 720 | ||||||||
| UniProtKB:A2VD33 | InterPro | 831 | ||||||||
| UniProtKB:A0AB32U145 | InterPro | 717 | ||||||||
| UniProtKB:A0AB32U4U6 | InterPro | 738 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available