ZFIN ID: ZDB-GENE-050327-93
Gene Name: EYA transcriptional coactivator and phosphatase 4
Gene Symbol: eya4    Nomenclature History

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Previous Names: im:7221408, zgc:113079

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have protein tyrosine phosphatase activity. Involved in embryonic organ development; posterior lateral line neuromast hair cell differentiation; and startle response. Predicted to localize to nucleus. Is expressed in several structures, including otic epithelium; otic vesicle; pericardial region; pharyngeal arch; and sensory system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 10; congestive heart failure; dilated cardiomyopathy; dilated cardiomyopathy 1J; and sensorineural hearing loss. Orthologous to human EYA4 (EYA transcriptional coactivator and phosphatase 4).
Genome Resources: Alliance (1),  Gene:541552 (1),  Ensembl(GRCz11):ENSDARG00000012397 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022652Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13475 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29968 Point Mutation Unknown Missense, Premature Stop ENU
    sa39420 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44021 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-eya4
    2
    CRISPR2-eya4
    3
    MO1-eya4 N/A 1
    MO2-eya4 N/A 1
    MO3-eya4 N/A 1
    DISEASE ASSOCIATED WITH eya4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 10 Alliance Deafness, autosomal dominant 10 601316
    dilated cardiomyopathy 1J Alliance ?Cardiomyopathy, dilated, 1J 605362
    DISEASE ASSOCIATED WITH eya4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart development (more)
    Cellular Component nucleus (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eya4-201 (1)    Ensembl 1974
    eya4-202 (1)    Ensembl 1911
    eya4-203 (1)    Ensembl 1911
    eya4-204 (1)    Ensembl 2414
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eya4 No data available
    MARKER RELATIONSHIPS
    eya4 Contained in: [BAC] DKEYP-79F12 (1)
    eya4 Encodes: [EST] IMAGE:7221408
    [cDNA] MGC:113079 (1), MGC:192621 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001282173 (1) 2890 nt
    Genomic GenBank:CR759830 (1) 196033 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IA41 (1) 638 aa
    Sequence Information (all 41)
    ORTHOLOGY for eya4 ( Chr: 23 )
    CITATIONS (33)