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General Information
ZIRC
ZFIN ID: ZDB-GENE-050327-8
Gene Name: presenilin associated, rhomboid-like a
Gene Symbol: parla    Nomenclature History

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Previous Names: parlb (1), zgc:112986

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have serine-type endopeptidase activity. Predicted to be involved in regulation of mitochondrion organization. Predicted to localize to the mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Is expressed in brain and liver. Orthologous to human PARL (presenilin associated rhomboid like).
Genome Resources: Alliance (1),  Gene:541485 (1),  Ensembl(GRCz11):ENSDARG00000039310 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:112986]
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-parla N/A 1
MO2-parla N/A 1
DISEASE ASSOCIATED WITH parla HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH parla VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process proteolysis (more)
Cellular Component integral component of membrane (more)
Molecular Function hydrolase activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR022764 (1)
  • InterPro:IPR035952 (1)
  • Pfam:PF01694 (1)
  • EC:3.4.21.105 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript parla-204 (1)    Ensembl 810
    mRNA parla-201 (1)    Ensembl 1613
    parla-202 (1)    Ensembl 889
    ncRNA parla-002 (1)    Ensembl 773
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM parla No data available
    MARKER RELATIONSHIPS
    parla Contained in: [BAC] CH211-170H3 (1) (order this)
    parla Encodes: [cDNA] MGC:112986 (1) (order this), MGC:191956 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001014298 (1) 1648 bp
    Genomic GenBank:CU467941 (1) 133979 bp
    Select Tool
    Polypeptide UniProtKB:B2GQL1 (1) 383 aa
    Sequence Clusters UniGene:20668 (1)
    Sequence Information (all 27)
    ORTHOLOGY for parla ( Chr: 2 )
    CITATIONS (19)