Gene
kcnab1a
- ID
- ZDB-GENE-050327-79
- Name
- potassium voltage-gated channel subfamily A regulatory beta subunit 1a
- Symbol
- kcnab1a Nomenclature History
- Previous Names
-
- kcnab1
- zgc:113627 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have aldo-keto reductase (NADP) activity; ion channel binding activity; and potassium channel regulator activity. Predicted to be involved in negative regulation of delayed rectifier potassium channel activity and oxidation-reduction process. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane; juxtaparanode region of axon; and voltage-gated potassium channel complex. Is expressed in immature eye; myotome; nervous system; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A member regulatory beta subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7159135 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR023210 | NADP-dependent oxidoreductase domain |
| Family | IPR005399 | Potassium channel, voltage-dependent, beta subunit, KCNAB-related |
| Family | IPR005400 | Potassium channel, voltage-dependent, beta subunit, KCNAB1 |
| Family | IPR005983 | Potassium channel, voltage-dependent, beta subunit, KCNAB |
| Homologous_superfamily | IPR036812 | NADP-dependent oxidoreductase domain superfamily |
Domain Details Per Protein
| Protein | Length | NADP-dependent oxidoreductase domain | NADP-dependent oxidoreductase domain superfamily | Potassium channel, voltage-dependent, beta subunit, KCNAB | Potassium channel, voltage-dependent, beta subunit, KCNAB1 | Potassium channel, voltage-dependent, beta subunit, KCNAB-related |
|---|---|---|---|---|---|---|
|
UniProtKB:Q58EC4
|
398 | |||||
|
UniProtKB:A0A8M9PQ73
|
403 | |||||
|
UniProtKB:A0A8M9PM35
|
423 | |||||
|
UniProtKB:A0A8M9PFF1
|
406 | |||||
|
UniProtKB:A0A8M9P126
|
418 | |||||
|
UniProtKB:A0A8M9PA23
|
411 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
kcnab1a-201
(1)
|
Ensembl | 2273 nt | |
| mRNA |
kcnab1a-202
(1)
|
Havana | 2355 nt |
Interactions and Pathways
No data available
Plasmids
No data available